Hongqiang Cheng Selected Research

Tyrosine (L-Tyrosine)

10/2017	Macrophage-Restricted Shp2 Tyrosine Phosphatase Acts as a Rheostat for MMP12 through TGF-β Activation in the Prevention of Age-Related Emphysema in Mice.
12/2014	SHP2 positively regulates TGFβ1-induced epithelial-mesenchymal transition modulated by its novel interacting protein Hook1.
9/2014	Myeloid-specific disruption of tyrosine phosphatase Shp2 promotes alternative activation of macrophages and predisposes mice to pulmonary fibrosis.
6/2012	Loss of Shp2 in alveoli epithelia induces deregulated surfactant homeostasis, resulting in spontaneous pulmonary fibrosis.

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Hongqiang Cheng Research Topics

Disease

8	Inflammation (Inflammations) 01/2023 - 06/2012
7	Neoplasms (Cancer) 01/2024 - 04/2010
5	Cardiomyopathies (Cardiomyopathy) 10/2019 - 02/2009
4	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2021 - 06/2012
4	Heart Failure 10/2013 - 02/2009
3	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 10/2019 - 08/2010
2	Thrombosis (Thrombus) 01/2024 - 11/2020
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2023 - 01/2019
2	Colitis 01/2023 - 01/2023
2	Lung Injury 03/2022 - 12/2016
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 03/2019
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 10/2020 - 01/2019
2	Vascular Remodeling 01/2020 - 12/2019
2	Neointima 01/2020 - 12/2019
2	Wounds and Injuries (Trauma) 01/2020 - 12/2016
2	Asthma (Bronchial Asthma) 11/2016 - 01/2016
2	Heart Diseases (Heart Disease) 04/2012 - 04/2010
1	Atherosclerosis 11/2023
1	Ischemic Stroke 05/2023
1	Hemorrhage 05/2023
1	Ischemia 05/2023
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 05/2023
1	Stomach Neoplasms (Stomach Cancer) 02/2023
1	Diabetic Neuropathies (Diabetic Neuropathy) 01/2023
1	Colorectal Neoplasms (Colorectal Cancer) 01/2023
1	Congenital Heart Defects (Congenital Heart Defect) 01/2023
1	Acute Lung Injury 12/2021
1	Fibrosis (Cirrhosis) 01/2021
1	Vascular System Injuries 01/2020
1	Noonan Syndrome (Female Pseudo-Turner Syndrome) 12/2019
1	LEOPARD Syndrome (Syndrome, LEOPARD) 12/2019
1	Lung Neoplasms (Lung Cancer) 01/2019
1	Sarcoma (Soft Tissue Sarcoma) 01/2019
1	Xerostomia 01/2018
1	Head and Neck Neoplasms (Head and Neck Cancer) 01/2018
1	Emphysema 10/2017
1	Pulmonary Emphysema 10/2017
1	Idiopathic Pulmonary Fibrosis 01/2017
1	Interstitial Lung Diseases (Interstitial Lung Disease) 12/2016
1	Pneumonia (Pneumonitis) 12/2016
1	Cardiac Sudden Death (Sudden Cardiac Arrest) 04/2015
1	Naxos disease 04/2015
1	Pulmonary Arterial Hypertension 03/2015
1	Schistosomiasis (Bilharziasis) 09/2014

Drug/Important Bio-Agent (IBA)

16	Proteins (Proteins, Gene)FDA Link 05/2023 - 02/2009
4	Non-Receptor Type 11 Protein Tyrosine PhosphataseIBA 03/2022 - 06/2012
4	Tyrosine (L-Tyrosine)FDA Link 10/2017 - 06/2012
3	Transforming Growth Factors (Transforming Growth Factor)IBA 05/2023 - 10/2020
3	Bleomycin (Blenoxane)FDA LinkGeneric 01/2021 - 09/2014
3	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2020 - 10/2017
3	Protein Tyrosine PhosphatasesIBA 12/2019 - 12/2014
2	SHP099IBA 01/2024 - 02/2023
2	Matrix Metalloproteinases (MMPs)IBA 01/2024 - 10/2017
2	Protein Kinases (Protein Kinase)IBA 01/2023 - 01/2020
2	CytokinesIBA 01/2019 - 01/2016
2	Surface-Active Agents (Surfactants)IBA 12/2016 - 06/2012
1	Apolipoproteins E (ApoE)IBA 11/2023
1	LDL Receptors (LDL Receptor)IBA 11/2023
1	Oxygen (Dioxygen)IBA 05/2023
1	Glucose (Dextrose)FDA LinkGeneric 05/2023
1	Nicotine FDA Link 05/2023
1	Tissue Plasminogen Activator (Alteplase)FDA Link 05/2023
1	Plasminogen Activators (Plasminogen Activator)IBA 05/2023
1	Tight Junction ProteinsIBA 05/2023
1	OccludinIBA 05/2023
1	AZD 6244IBA 02/2023
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 02/2023
1	Dextrans (Dextran)FDA Link 01/2023
1	epalrestatIBA 01/2023
1	N-propionylprocainamideIBA 01/2023
1	SugarsIBA 01/2023
1	Mannose (D-Mannose)IBA 01/2023
1	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2023
1	Therapeutic UsesIBA 01/2023
1	LipidsIBA 01/2022
1	EnzymesIBA 12/2021
1	T Cell Transcription Factor 1IBA 11/2021
1	Glycoproteins (Glycoprotein)IBA 01/2021
1	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 01/2021
1	Small Interfering RNA (siRNA)IBA 01/2021
1	IntegrinsIBA 11/2020
1	Leucine-Rich Repeat ProteinsIBA 01/2020
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2020
1	Nitric Oxide Synthase (NO Synthase)IBA 01/2020
1	LipopolysaccharidesIBA 01/2020
1	CollagenIBA 12/2019
1	Epidermal Growth Factor (EGF)IBA 03/2019
1	tanyu tongzhi formulaIBA 03/2019
1	Carrier Proteins (Binding Protein)IBA 01/2019
1	Interleukin-10 (Interleukin 10)IBA 01/2019
1	Pancreatic Elastase (Elastase)IBA 10/2017
1	Interleukin-4 (Interleukin 4)IBA 01/2017
1	GlucocorticoidsIBA 01/2016
1	gamma Catenin (Plakoglobin)IBA 04/2015
1	MicroRNAs (MicroRNA)IBA 03/2015

Therapy/Procedure

2	Therapeutics 02/2023 - 11/2021
2	Radiotherapy 03/2022 - 01/2018
2	Ligation 01/2020 - 12/2019
1	Contraindications 01/2024
1	Immunotherapy 01/2023